Background: De Quervain's Tenosynovitis (DQT) is a highly frequent condition affecting all age of people, identified by inflammation in abductor pollicis longus (APL) and extensor pollicis brevis (EPB) that run along the thumb side of the wrist and attach to the base of the thumb. It is commonly associated with repetitive strain and overuse, particularly individuals engaged in manual labor or activities requiring sustained wrist movements. Aim: This study aimed to analyze the characteristics and relevant factors of individuals diagnosed with De Quervain's Tenosynovitis (DQT) in Bangladesh. Methods: A cross-sectional quantitative study was conducted with 60 participants receiving DQT treatment at the Centre for Rehabilitation of the Paralysed (CRP). Data were collected through face-to-face surveys using a self-developed questionnaire. Results: The study included 60 patients where 68.3% were female, with average age 39.55. The dominant hand was affected in 80% of the cases, with 51.7% of the right hands. The commonest symptom reported was pain in (91.7%), whereas 65.5% had extreme pain during thumb movements. Occupational risk factors were identified in 100% of participants, with repetitive hand and wrist activities being the predominant contributing factor. Most participants 71.7% reported the frequent usage of smartphones or computers, and 30.2% used devices over 6 hours per day. 61.7% of participants rated ergonomic practices as "fair," and 45% reported they did not take breaks during repetitive tasks. Conclusion: This study shows that De Quervain's Tenosynovitis (DQT) has a strong correlation with repetitive activities in which the female gender and dominant hand are highly vulnerable. It highlights the significance of ergonomic knowledge, workplace modification, and targeted intervention adopted to control and prevent DQT